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St. John’s wort – Mayo Clinic

Overview

St. John’s wort (Hypericum perforatum) is a flowering shrub native to Europe. It will get its identify from the fact that it generally blooms on the birthday of the biblical John the Baptist.

The bouquets and leaves of St. John’s wort comprise lively components these as hyperforin. St. John’s wort is obtainable as a supplement in teas, tablets, liquids and topical preparations.

Persons use St. John’s wort to treat depression and menopausal symptoms.

Evidence

Analysis on St. John’s wort use for specific circumstances exhibits:

  • Depression. Numerous research assist the therapeutic benefit of St. John’s wort in dealing with delicate to moderate depression. In fact, some analysis has demonstrated the supplement to be as successful as quite a few prescription antidepressants. It can be unclear whether or not it’s advantageous in the remedy of critical depression. Simply because St. John’s wort interacts with several prescription drugs, it could possibly not be an suitable option, significantly if you consider any prescription medicines.
  • Menopausal symptoms. Some proof suggests that having St. John’s wort by yourself or in blend with black cohosh or other herbs could possibly lessen menopausal symptoms these as warm flashes.
  • Somatic symptom disorder. Some research suggest that St. John’s wort could possibly be advantageous for the remedy of this affliction that causes critical panic about actual physical symptoms these as soreness, weak point or shortness of breath.

Our consider

Yellow light: Caution

Caution

St. John’s wort can be successful for dealing with delicate to moderate depression. Even so, the supplement interacts with several prescription drugs and can bring about really serious facet results. Consult with your medical professional in advance of having St. John’s wort if you consider any other prescription drugs.

Basic safety and facet results

When taken orally for up to twelve weeks in suitable doses, St. John’s wort is generally viewed as risk-free. Even so, it may bring about:

  • Agitation and panic
  • Dizziness
  • Diarrhea, constipation and abdomen pain
  • Dry mouth

Other facet results may involve:

  • Tiredness and insomnia
  • Headache
  • Enhanced sensitivity to sunlight (photosensitivity)

There is not sufficient information and facts about the safety of making use of St. John’s wort topically.

You should not use St. John’s wort in the course of being pregnant or when breastfeeding.

Interactions

The record under contains some recognized interactions. Even so, other medicines may also interact with St. John’s wort. Check out with your medical professional in advance of making use of St. John’s wort in blend with any other medicines, specially prescription prescription drugs.

  • Alprazolam (Xanax). Using St. John’s wort with this drug applied to decrease symptoms of panic could possibly decrease the drug’s result.
  • Antidepressants. Using St. John’s wort with antidepressants could possibly maximize the possibility of the accumulation of high levels of serotonin in your physique. Also significantly serotonin can bring about delicate to critical facet results. Using this supplement and an antidepressant necessitates a doctor’s supervision.
  • Barbiturates. Using St. John’s wort with a drug that functions as a central nervous method depressant (barbiturate) could possibly decrease barbiturate-induced sleep time.
  • Bupropion (Wellbutrin SR, Forfivo XL). Using St. John’s wort with this antidepressant could possibly decrease the drug’s result.
  • Specified chemotherapy medicines. Using St. John’s wort with irinotecan (Camptosar, Onivyde), docetaxel (Taxotere) or imatinib (Gleevec) could possibly lessen the chemotherapy drug’s results.
  • Specified immunosuppressive medicines. Using St. John’s wort with tacrolimus (Prograf, Astagraf XL, other individuals) or cyclosporine (Neoral, Sandimmune, other individuals) could possibly decrease the drug’s result.
  • Specified statins. Using St. John’s wort with simvastatin (Zocor, Flolipid) could possibly lessen the drug’s usefulness.
  • Contraceptive medicines. Use of St. John’s wort with contraceptive medicines could possibly consequence in breakthrough bleeding, irregular bleeding or unplanned being pregnant. An more or alternative kind of delivery control could possibly be necessary.
  • Cytochrome P450 1A2 (CYP1A2), Cytochrome P450 2B6 (CYP2B6), Cytochrome P450 2C19 (CYP2C19) and cytochrome P450 2C9 (CYP2C9) and cytochrome P450 3A4 (CYP3A4) substrates. You should not consider St. John’s wort if you might be having a drug influenced by these enzymes.
  • Dextromethorphan. Using St. John’s wort with this cough suppressant could possibly maximize the possibility of the accumulation of high levels of serotonin in your physique.
  • Digoxin (Lanoxin). Using St. John’s wort with this heart medication can lessen the drug’s result.
  • Fexofenadine (Allegra Allergy). Using St. John’s wort with this antihistamine could possibly bring about way too significantly of the drug to create up in your physique, worsening common facet results.
  • Ketamine (Ketalar). Using St. John’s wort with ketamine could possibly lessen the drug’s anesthetic result.
  • Narcotics. You should not consider St. John’s wort with methadone (Methadose). Using St. John’s wort with specific narcotics could possibly lessen the drug’s usefulness. Combining the supplement with narcotics could possibly also maximize narcotic-induced sleep time and painkilling results.
  • Non-nucleoside reverse transcriptase inhibitors. Using St. John’s wort with 1 of these anti-HIV medicines could lessen the drug’s result.
  • Omeprazole (Prilosec). You should not consider St. John’s wort with this drug applied to treat persistent heartburn. The supplement can lessen the drug’s usefulness.
  • Phenytoin (Dilantin, Phenytek). Using St. John’s wort with this anticonvulsant could possibly consequence in reduction of seizure control.
  • Photosensitizing medicines. Using St. John’s wort with a drug that raises sensitivity to sunlight could possibly maximize the possibility of a response.
  • Protease inhibitors. Using St. John’s wort with this kind of antiviral drug can lessen the drug’s usefulness.
  • Triptans. You should not consider St. John’s wort with these prescription drugs applied to treat migraines. The supplement could possibly maximize the possibility of the accumulation of high levels of serotonin in your physique. Also significantly serotonin can bring about delicate to critical facet results.
  • Voriconazole. Using St. John’s wort with this antifungal drug could possibly lessen the drug’s usefulness.
  • Warfarin (Jantoven). Using St. John’s wort with this drug taken to lessen blood clotting could possibly decrease the drug’s result.

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