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DHEA – Mayo Clinic

Overview

Dehydroepiandrosterone (DHEA) is a hormone that your overall body the natural way produces in the adrenal gland. DHEA aids develop other hormones, which includes testosterone and estrogen. Normal DHEA ranges peak in early adulthood and then bit by bit slide as you age.

A artificial version of DHEA is out there as a pill, capsule, powder, topical product and gel.

Men and women use DHEA as an anti-aging treatment and to improve bodily functionality. DHEA is also employed to deal with despair and signs and symptoms of menopause.

Evidence

Analysis on DHEA for certain problems involves:

  • Ageing. In idea, using DHEA health supplements to sustain DHEA ranges could sluggish the aging course of action, maybe improving very well-becoming, cognitive function and overall body composition. But so significantly research hasn’t proved this to be legitimate. Extra research are essential to improved understand whether DHEA supplementation can counteract some of the results of aging. A smaller study advised that using DHEA health supplements may possibly improve pores and skin hydration and firmness, and decrease aging spots in aged adults.
  • Melancholy. DHEA may possibly be far more effective at managing despair than placebo, especially in persons with minimal DHEA ranges.
  • Osteoporosis. Analyze results on the results of DHEA supplementation in the therapy of osteoporosis are combined. Extra research is essential to determine whether using DHEA health supplements improves bone density in more mature adults with minimal DHEA.
  • Vaginal atrophy. Constrained research implies that DHEA may possibly improve vaginal dryness in postmenopausal females.

Analysis on the results of DHEA on muscle mass toughness and bodily functionality experienced combined results, but most research point out DHEA supplementation has no result on muscle mass toughness in more youthful or more mature adults. The Countrywide Collegiate Athletic Affiliation has banned DHEA use among the athletes.

DHEA may possibly eventually prove to have benefits in managing persons identified with selected problems, these as adrenal insufficiency and lupus. On the other hand, even further research are essential.

Research have revealed excellent manage of this supplement to frequently be minimal.

Our consider

Red light: Avoid

Avoid

Although some research implies that DHEA may possibly be marginally handy in managing despair and vaginal atrophy, there is certainly minor proof to assistance anti-aging claims. Also, DHEA use can result in really serious facet results. Avoid employing this supplement.

Protection and facet results

DHEA is a hormone. Use of this supplement may possibly boost ranges of androgen and have a steroid result. DHEA also may possibly boost the possibility of hormone-sensitive cancers, which includes prostate, breast and ovarian cancers. If you have any sort of cancer or are at possibility of cancer, don’t use DHEA.

Don’t use DHEA if you are pregnant or breastfeeding.

Think about preventing use of DHEA if you have significant cholesterol or a situation that has an effect on the provide of blood to the coronary heart (ischemic coronary heart disorder). DHEA may possibly lower significant-density lipoprotein (HDL), or “great,” cholesterol ranges.

Use of DHEA also may possibly worsen psychiatric disorders and boost the possibility of mania in persons who have temper disorders.

DHEA also may possibly result in oily pores and skin, acne and unwanted, male-pattern hair progress in females (hirsutism).

Interactions

Doable interactions include:

  • Antipsychotics. Use of DHEA with antipsychotics these as clozapine (Clozaril, Versacloz, many others) may possibly lower the drug’s efficiency.
  • Carbamazepine (Tegretol, Carbatrol, many others). Use of DHEA with this drug employed to deal with seizures, nerve discomfort and bipolar disorder may possibly lower the drug’s efficiency.
  • Estrogen. Don’t use DHEA with estrogen. Combining DHEA and estrogen may possibly result in signs and symptoms of excess estrogen, these as nausea, headache and insomnia.
  • Lithium. Use of DHEA with lithium may possibly lower the drug’s efficiency.
  • Selective serotonin reuptake inhibitors. Use of DHEA with this style of antidepressant may possibly result in manic signs and symptoms.
  • Testosterone. Don’t use DHEA with testosterone. Combining DHEA and testosterone may possibly result in signs and symptoms these as minimal sperm rely and enlarged breasts in guys (gynecomastia) and the advancement of normally male attributes in females.
  • Triazolam (Halcion). Making use of DHEA with this sedative may possibly boost the results of this drug, producing abnormal sedation and affecting your respiration and coronary heart amount.
  • Valproic acid. Use of DHEA with this medication employed to deal with seizures and bipolar disorder may possibly lower the drug’s efficiency.

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