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COVID-19 Vaccines for Moderately to Severely Immunocompromised People

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How very long just after getting my first COVID-19 vaccines can I get an extra dose?

CDC endorses the extra dose of an mRNA COVID-19 vaccine be administered at least 4 months just after a next dose of Pfizer-BioNTech COVID-19 vaccine or Moderna COVID-19 vaccine.

Can you mix and match the vaccines?

For individuals who obtained both Pfizer-BioNTech or Moderna’s COVID-19 vaccine sequence, a third dose of the exact same mRNA vaccine need to be utilised. A individual need to not obtain much more than a few mRNA vaccine doses. If the mRNA vaccine product or service provided for the initially two doses is not readily available or is unidentified, both mRNA COVID-19 vaccine product or service may perhaps be administered.

What need to immunocompromised individuals who obtained the J&J/Janssen vaccine do?

The FDA’s current EUA amendment only applies to mRNA COVID-19 vaccines, as does CDC’s advice.

Rising facts have demonstrated that immunocompromised individuals who have low or no security subsequent two doses of mRNA COVID-19 vaccines may perhaps have an improved reaction just after an extra dose of the exact same vaccine. There is not plenty of facts at this time to determine whether immunocompromised individuals who obtained the Johnson & Johnson’s Janssen COVID-19 vaccine also have an improved antibody reaction subsequent an extra dose of the exact same vaccine.

What are the advantages of individuals obtaining an extra vaccine dose?

An extra dose may perhaps prevent major and quite possibly daily life-threatening COVID-19 in individuals who may perhaps not have responded to their first vaccine sequence. In ongoing clinical trials, the mRNA COVID-19 vaccines (Pfizer-BioNTech or Moderna) have been revealed to prevent COVID-19 subsequent the two-dose sequence. Minimal information and facts suggests that immunocompromised individuals who have low or no security just after two doses of mRNA vaccines may perhaps have an improved reaction just after an extra dose of the exact same vaccine.

What are the hazards of vaccinating people today with an extra dose?

There is restricted information and facts about the hazards of obtaining an extra dose of vaccine, and the security, efficacy, and reward of extra doses of COVID-19 vaccine in immunocompromised individuals continues to be evaluated. So significantly, reactions described just after the third mRNA dose were being identical to that of the two-dose sequence: fatigue and discomfort at injection web-site were being the most typically described aspect outcomes, and overall, most indicators were being mild to average.

Even so, as with the two-dose sequence, major aspect outcomes are rare, but may perhaps manifest.